SidaGhanaV1, Main, Exploration, bibRecord, 000789

Prevalence and Impact of Hepatitis B and C Virus Co-Infections in Antiretroviral Treatment Naive Patients With HIV Infection at a Major Treatment Center in Ghana

Identifieur interne : 000789 ( Main/Exploration ); précédent : 000788; suivant : 000790

Prevalence and Impact of Hepatitis B and C Virus Co-Infections in Antiretroviral Treatment Naive Patients With HIV Infection at a Major Treatment Center in Ghana

Auteurs : Kwamena William Coleman Sagoe [Ghana] ; Afrakoma Adjoa Agyei [Ghana] ; Francesca Ziga [Ghana] ; Margaret Lartey [Ghana] ; Theophilus K. Adiku [Ghana] ; Makafui Seshi Max Q. Arens [États-Unis] ; Julius Abraham Addo Mingle [Ghana]

Source :

Journal of medical virology [ 0146-6615 ] ; 2012.

RBID : Pascal:12-0195630

Descripteurs français

Pascal (Inist)
- Virus hépatite C, Virus hépatite B, Virus immunodéficience humaine, Prévalence, Epidémiologie, Antiviral, Antirétroviral, Traitement, Charge virale, Hépatite, Infection mixte, SIDA, Antigène CD4.

English descriptors

KwdEn :
- AIDS, Antiretroviral agent, Antiviral, Epidemiology, Hepatitis, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Mixed infection, Prevalence, Treatment, Viral load.

Abstract

Data on the effects of the presence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients co-infected with these viruses and HIV in West Africa are conflicting and little information is available in Ghana. A cohort of 138 treatment naïve individuals infected with HIV was screened for HBV and HCV serologic markers; HBsAg positive patients were tested for HBeAg, anti-HBe, and anti-HBc IgM. The viral load of HIV-1 in the plasma was determined in 81 patients. Eighteen of the 138 patients (13%) and 5 (3.6%) had HBsAg and anti-HCV, respectively. None of the patients had anti-HBc IgM, but 10 (55.6%) and 8 (44.4%) of the 18 patients who were HBsAg positive had HBeAg and anti-HBe, respectively. In patients with measurement of CD4⁺ undertaken within 1 month (n = 83), CD4⁺ count was significantly lower in patients with HBeAg (median [IQR], 81 [22-144]) as compared to those with anti-HBe (median [IQR], 210 [197-222]) (P= 0.002, CI: -96.46 to 51.21). However, those with HIV mono-infection had similar CD4⁺ counts (median [IQR], 57 [14-159]) compared to those with HBeAg (P= 1.0, CI: -71.75 to 73.66). Similar results were obtained if CD4⁺ count was measured within 2 months prior to initiation of HAART (n = 119). Generally, HBV and anti-HCV did not affect CD4⁺ and viral loads of HIV-1 in plasma but patients with HIV and HBV co-infection who had HBeAg had more severe immune suppression as compared to those with anti-HBe. This may have implication for initiating HAART in HBV endemic areas.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Retrovirus Laboratory, Department of Pediatrics, Washington University Medical School</s1>
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<series><title level="j" type="main">Journal of medical virology</title>
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<term>Hepatitis</term>
<term>Hepatitis B virus</term>
<term>Hepatitis C virus</term>
<term>Human immunodeficiency virus</term>
<term>Mixed infection</term>
<term>Prevalence</term>
<term>Treatment</term>
<term>Viral load</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus hépatite C</term>
<term>Virus hépatite B</term>
<term>Virus immunodéficience humaine</term>
<term>Prévalence</term>
<term>Epidémiologie</term>
<term>Antiviral</term>
<term>Antirétroviral</term>
<term>Traitement</term>
<term>Charge virale</term>
<term>Hépatite</term>
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<front><div type="abstract" xml:lang="en">Data on the effects of the presence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients co-infected with these viruses and HIV in West Africa are conflicting and little information is available in Ghana. A cohort of 138 treatment naïve individuals infected with HIV was screened for HBV and HCV serologic markers; HBsAg positive patients were tested for HBeAg, anti-HBe, and anti-HBc IgM. The viral load of HIV-1 in the plasma was determined in 81 patients. Eighteen of the 138 patients (13%) and 5 (3.6%) had HBsAg and anti-HCV, respectively. None of the patients had anti-HBc IgM, but 10 (55.6%) and 8 (44.4%) of the 18 patients who were HBsAg positive had HBeAg and anti-HBe, respectively. In patients with measurement of CD4<sup>+</sup>
 undertaken within 1 month (n = 83), CD4<sup>+</sup>
 count was significantly lower in patients with HBeAg (median [IQR], 81 [22-144]) as compared to those with anti-HBe (median [IQR], 210 [197-222]) (P= 0.002, CI: -96.46 to 51.21). However, those with HIV mono-infection had similar CD4<sup>+</sup>
 counts (median [IQR], 57 [14-159]) compared to those with HBeAg (P= 1.0, CI: -71.75 to 73.66). Similar results were obtained if CD4<sup>+</sup>
 count was measured within 2 months prior to initiation of HAART (n = 119). Generally, HBV and anti-HCV did not affect CD4<sup>+</sup>
 and viral loads of HIV-1 in plasma but patients with HIV and HBV co-infection who had HBeAg had more severe immune suppression as compared to those with anti-HBe. This may have implication for initiating HAART in HBV endemic areas.</div>
</front>
</TEI>
<affiliations><list><country><li>Ghana</li>
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<name sortKey="Addo Mingle, Julius Abraham" sort="Addo Mingle, Julius Abraham" uniqKey="Addo Mingle J" first="Julius Abraham" last="Addo Mingle">Julius Abraham Addo Mingle</name>
<name sortKey="Adiku, Theophilus K" sort="Adiku, Theophilus K" uniqKey="Adiku T" first="Theophilus K." last="Adiku">Theophilus K. Adiku</name>
<name sortKey="Adjoa Agyei, Afrakoma" sort="Adjoa Agyei, Afrakoma" uniqKey="Adjoa Agyei A" first="Afrakoma" last="Adjoa Agyei">Afrakoma Adjoa Agyei</name>
<name sortKey="Lartey, Margaret" sort="Lartey, Margaret" uniqKey="Lartey M" first="Margaret" last="Lartey">Margaret Lartey</name>
<name sortKey="Ziga, Francesca" sort="Ziga, Francesca" uniqKey="Ziga F" first="Francesca" last="Ziga">Francesca Ziga</name>
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<country name="États-Unis"><region name="Missouri (État)"><name sortKey="Arens, Makafui Seshi Max Q" sort="Arens, Makafui Seshi Max Q" uniqKey="Arens M" first="Makafui Seshi Max Q." last="Arens">Makafui Seshi Max Q. Arens</name>
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	Le SIDA au Ghana (serveur d'exploration)
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Le SIDA au Ghana (serveur d'exploration)

Prevalence and Impact of Hepatitis B and C Virus Co-Infections in Antiretroviral Treatment Naive Patients With HIV Infection at a Major Treatment Center in Ghana

Prevalence and Impact of Hepatitis B and C Virus Co-Infections in Antiretroviral Treatment Naive Patients With HIV Infection at a Major Treatment Center in Ghana

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri